Phenylpropanoids and polyketides
Apexbio Technology LLC Tyrphostin 9 10537-47-0 25mg
Tyrphostin 9 is a selective inhibitor targeting platelet-derived growth factor receptor (PDGFR) and epidermal growth factor receptor (EGFR) It inhibits PDGFR autophosphorylation with an IC50 of approximately 2 5 M and EGFR kinase activity (IC50 around 460 M) Additionally Tyrphostin 9 inhibits platelet-derived growth factor (PDGF)-stimulated smooth muscle cell proliferation (IC50 approximately 40 nM) as well as phosphorylation of phospholipase C gamma (PLC IC50 2 5 M) and induction of PDGF-dependent c-fos expression In research models Tyrphostin 9 has been utilized to study receptor-mediated signal transduction and vascular injury-related neointimal proliferation processes
Medchemexpress LLC (4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one | 100667-52-5 | >98.0% | C19H20O2 | 10MG
(4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one (CAS 100667-52-5) is a diarylheptanoid research chemical used as a biochemical reagent for laboratory studies. It appears as a white to off-white solid and is characterized by molecular formula C19H20O2 and a molecular weight of 280.4 g/mol. The compound is provided in small research-scale quantities for analytical, assay, and synthetic applications.
- High purity (>98.0%).
- Accurate molecular formula C19H20O2.
- Suitable for assay and analytical use in research settings.
- Supplied in small milligram package sizes for laboratory workflows.
- Includes standard structural identifiers for cheminformatics (SMILES, InChIKey).
eMolecules 2699937-04-5 | Medchem Express | MRL-494 (hydrochloride) | 5mg | 552386588 | HY-128773A | 659.13 | C26H36ClFN16O2
Medchem Express | Apramycin (sulfate) | 100mg | 446273816 | HY-B1329 | 65710-07-8 | 637.660 | C21H43N5O15S
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Selleck Chemical LLC Tyrphostin AG-528
Tyrphostin AG-528 (Tyrphostin B66) is a potent inhibitor of epidermal growth factor receptors (EGFR) and ErbB2/HER2 with IC50 of 4 9 M and 2 1 M respectively Tyrphostin AG-528 exhibits anticancer activity
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 10 MG
Tyrphostin A1 (AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It is for research use only.
- Inhibits CD40L-stimulated IL-12 production in macrophage cultures
- Decreases IL-12 p40 production in a dose-dependent manner
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Reduces activation of IL-12 p40 gene
- Leads to a decrease in the generation of myelin basic protein (MBP) specific encephalitogenic T cells in vivo therapy
- Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
- Weaker inhibitor of TK compared to other tyrphostins, useful for differentiating TK-mediated effects
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 100 MG
Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. It causes a dose-dependent decrease of IL-12 p40 and blocks CD40L-induced translocation of NF-κB to the nucleus, reducing activation of the IL-12 p40 gene. This compound is a weaker inhibitor of TK, often used to differentiate TK-mediated effects from other non-specific effects.
- Inhibits CD40L-stimulated IL-12 production
- Reduces antigen-induced generation of Th1 cells
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Attenuates experimental allergic encephalomyelitis (EAE) in SJL/J mice
- Useful for differentiating TK-mediated effects from non-specific effects
- For research use only
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.6% | 339.39 | 5 MG
Curcumin 5-8 is a potent and orally active natural curcumin analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. It also improves insulin resistance and insulin sensitivity.
- Inhibits lipid droplet formation.
- Increases autophagy.
- Inhibits apoptosis.
- Improves insulin resistance.
- Improves insulin sensitivity.
Apexbio Technology LLC Entacapone sodium salt 1047659-02-8 100mg
Entacapone sodium salt (CAS 1047659-02-8) is a nitrocatechol small molecule that acts as a selective and reversible inhibitor of catechol-O-methyltransferase (COMT) a Mg2 -dependent enzyme involved in the metabolism of catecholamines and related compounds In biochemical assays entacapone exhibits an IC50 of 20 1 nM and a Ki of 10 7 nM for COMT inhibition The presence of a nitro group ortho to the hydroxyl group in its structure contributes to its inhibitory potency Entacapone has been widely used in research focused on Parkinson s disease particularly to study the modulation of levodopa bioavailability and pharmacokinetics
Medchemexpress LLC Tyrphostin AG 528 | 133550-49-9 | MFCD01076474 | 98.0% | 306.32 | C18H14N2O3 | 10 MG
Tyrphostin AG 528 is a small-molecule protein tyrosine kinase inhibitor used as a research reagent for biochemical and cellular studies targeting EGFR and ErbB2. It is supplied as a solid with high purity and defined storage recommendations for long-term stability.
- Small-molecule inhibitor selective for EGFR and ErbB2.
- Reported IC50: EGFR 4.9 μM, ErbB2 2.1 μM.
- High purity (98.0%) suitable for preclinical research.
- Solid, light yellow to yellow appearance for easy handling.
- Molecular weight 306.32 and formula C18H14N2O3 for characterization.
- Available in small pack sizes for screening and assay development.
- Recommended storage: powder at -20°C (3 years) or 4°C (2 years).
TARGETMOL CHEMICALS INC SAR405 R enantiomer 5MG
Also available in 1 mL, 1 mg, 2 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes.SAR405 (R enantiomer) is the less active form of SAR405, an inhibitor of PIK3C3/Vps34. Purity 98.04%
TARGETMOL CHEMICALS INC POLYINOSINIC-POLYCYTIDYL 25MG
Also available in 5 mg 10 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Polyinosinic-polycytidylic acid (Poly(IC)) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-like receptor- 3 (TLR3) agonist. purity: 98%
Apexbio Technology LLC Tyrphostin 9 10537-47-0 10mM (in 1mL DMSO)
Tyrphostin 9 is a selective inhibitor targeting platelet-derived growth factor receptor (PDGFR) and epidermal growth factor receptor (EGFR) It inhibits PDGFR autophosphorylation with an IC50 of approximately 2 5 M and EGFR kinase activity (IC50 around 460 M) Additionally Tyrphostin 9 inhibits platelet-derived growth factor (PDGF)-stimulated smooth muscle cell proliferation (IC50 approximately 40 nM) as well as phosphorylation of phospholipase C gamma (PLC IC50 2 5 M) and induction of PDGF-dependent c-fos expression In research models Tyrphostin 9 has been utilized to study receptor-mediated signal transduction and vascular injury-related neointimal proliferation processes
eMolecules 69038-81-9 | 2-Ethoxycinnamic acid | Chem-Impex192.214 | C11H12O3 | 99.000 | CCOc1ccccc1C=CC(O)=O | 5g | 386901291
2-Ethoxycinnamic acid | Chem-Impex | 69038-81-9192.214 | C11H12O3 | 99.000 | CCOc1ccccc1C=CC(O)=O | 5g | 386901291
Medchemexpress LLC 3-Methylcinnamic acid | 3029-79-6 | 99.8% | C10H10O2 | 25 G
3-Methylcinnamic acid is a drug intermediate for the synthesis of various active compounds. This product is intended for research use only and is not sold to patients. It typically appears as a white to off-white solid.
- Drug intermediate for synthesis of various active compounds
- For research use only
- Appears as a white to off-white solid
- Molecular weight of 162.19
- Powder storage: -20°C for 3 years or 4°C for 2 years
- In solvent storage: -80°C for 6 months or -20°C for 1 month
Pfaltz & Bauer 2 4-Dimethoxycinnamic Acid 97 25G | 6972-61-8
2 4-Dimethoxycinnamic Acid 97 25G | 6972-61-8
